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Anesth Analg 2006;103:545-550
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000229709.29185.88

CARDIOVASCULAR ANESTHESIA

Diabetes Mellitus Reduces the Antiarrhythmic Effect of Ion Channel Blockers

Isao Ito, MD, Yukio Hayashi, MD, Yusuke Kawai, MD, Mitsuo Iwasaki, MD, Koji Takada, MD, Takahiko Kamibayashi, MD, Atsushi Yamatodani, MD*, and Takashi Mashimo, MD

From the Department of Anesthesiology and *Department of Medical Physics, School of Allied Health Sciences, Osaka University Faculty of Medicine, Osaka, Japan.

Address correspondence and reprint requests to Yukio Hayashi, MD, Department of Anesthesiology, Osaka University Faculty of Medicine (D-7), 2-2, Yamada-oka, Suita, Osaka 565-0871, Japan. Address e-mail to yhayashi{at}anes.med.osaka-u.ac.jp.

We designed the present study to examine whether diabetes mellitus affects the antiarrhythmic effect of flecainide, a sodium channel blocker, E-4031, a potassium channel blocker, and verapamil, a calcium channel blocker, in diabetic rats. The experiments were performed in intact and diabetic rats 2, 4, and 6 wk after administration of streptozotocin. Rats were anesthetized with halothane and monitored continuously for arterial blood pressure and premature ventricular contractions. The arrhythmogenic dose of epinephrine was defined as the smallest dose producing 3 or more premature ventricular contractions within a 15-s period. The arrhythmogenic doses of epinephrine in the presence of flecainide were 8.2 ± 2.2 (mean ± sd), 7.4 ± 6.1, 5.5 ± 2.8, and 2.0 ± 0.5 µg/kg in intact and diabetic rats 2, 4, and 6 wk after streptozotocin administration, respectively. Similarly, the arrhythmogenic doses of epinephrine in the presence of E-4031 were 7.7 ± 2.6, 2.3 ± 0.7, 2.0 ± 0.7, and 1.2 ± 0.5 µg/kg, and those in the presence of verapamil were 8.2 ± 2.1, 3.1 ± 1.2, 2.3 ± 0.9, and 1.5 ± 0.5 µg/kg. Insulin partially recovered the antiarrhythmic effect of the blockers. We concluded that diabetes mellitus reduces the antiarrhythmic effects of flecainide, E-4031, and verapamil.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.