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Anesth Analg 2006;103:594-600
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000229853.01875.60

ANESTHETIC PHARMACOLOGY

Propofol Attenuates Ovalbumin-Induced Smooth Muscle Contraction of the Sensitized Rat Trachea: Inhibition of Serotonergic and Cholinergic Signaling

Masakazu Yamaguchi, MD, Osamu Shibata, MD, Kenji Nishioka, MD, Tetsuji Makita, MD, and Koji Sumikawa, MD

From the Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, Japan.

Address correspondence to: Osamu Shibata MD, Department of Anesthesiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Address e-mail to opshiba{at}net.nagasaki-u.ac.jp.

Propofol is considered suitable for induction of anesthesia in patients with bronchial asthma. However, the mechanisms of its action on bronchi are not fully understood. We examined the effects of propofol on ovalbumin (OA)-induced contraction of OA-sensitized rat trachea. Male Wistar rats were sensitized by a single intraperitoneal injection of OA 10 µg mixed with aluminum hydroxide, 10 mg, as adjuvant. Fourteen days later, the experiment was performed using the tracheal rings. We observed the effects of ketanserin, a 5-HT2 receptor antagonist, and atropine on OA-induced contraction. Next, the effects of propofol on OA-, serotonin (5-HT)-, acetylcholine-, or electrical field stimulation-induced contractions were observed. OA-induced contraction was 90% attenuated by the combination of ketanserin and atropine. Propofol significantly attenuated OA-induced contraction in a dose-dependent manner. Propofol abolished 5-HT-induced contraction, attenuated acetylcholine-induced contraction, and also almost completely attenuated the enhancement by 5-HT of electrical field stimulation-induced contraction. These results suggest that the mechanism involved in the attenuation by propofol of OA-induced contraction is inhibition of the actions of 5-HT. Propofol should be a useful anesthetic in patients with immunoglobulin E-related asthma.




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 Anesth. Analg.Home page
K. Nishioka, O. Shibata, M. Yamaguchi, T. Makita, and K. Sumikawa
The Effects of Fentanyl on the Contractile Response of Ovalbumin-Sensitized Rat Trachea
Anesth. Analg., May 1, 2007; 104(5): 1103 - 1108.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.