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Anesth Analg 2006;103:714-720
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000226100.46866.ea

ANALGESIA

Intermittent Lumbar Puncture in Rats: A Novel Method for the Experimental Study of Opioid Tolerance

Jijun J. Xu, MD*{dagger}, Brittan C. Walla, BS*, Miguel F. Diaz, BS*, Gregory N. Fuller, MD, PhD{ddagger}, and Howard B. Gutstein, MD*{dagger}

From the *Department of Anesthesiology and Molecular Genetics, Program in Genes and Development, Graduate School of Biomedical Sciences, and {ddagger}Department of Pathology, University of Texas, M.D. Anderson Cancer Center, Houston.

Abstract

Spinal subarachnoid opioid administration in rats has been a very important method for studying the pharmacological effects of opioids, including analgesia and tolerance. Intrathecal catheterization, either through the cervical or lumbar approach, has been the predominant method used to deliver opioids spinally. However, these methods have potential undesirable complications. To help mitigate these problems, we have developed a method of intermittent lumbar puncture in rats to study the effects of chronic spinal opioid administration. This method avoids catheter-associated morbidity. We demonstrate that this method can be readily used to induce spinal opioid tolerance without causing morbidity. Intermittent lumbar puncture should prove to be a useful technique for investigating mechanisms of spinal opioid analgesia and opioid tolerance development.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.