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Anesth Analg 2006;103:1229-1236
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000237401.22688.22

NEUROSURGICAL ANESTHESIA

Computed Tomography-Estimated Specific Gravity of Noncontused Brain Areas as a Marker of Severity in Human Traumatic Brain Injury

Vincent Degos, MD*, Thomas Lescot, MD*, Abderrezak Zouaoui, MD, PhD{dagger}, Harold Hermann, MD*, Françoise Préteux, PhD{ddagger}, Pierre Coriat, MD*, and Louis Puybasset, MD, PhD*

From the Departments of *Anesthesiology and Critical Care and {dagger}Neuroradiology, Centre Hospitalo-Universitaire (CHU) Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris; Université Pierre et Marie Curie-Paris6, France; and {ddagger}Artemis Project Unit, Institut National des Télécommunications, Evry, France.

Address correspondence and reprint requests to Louis Puybasset, MD, PhD, Unité de Neuroréanimation, Département d'Anesthésie-Réanimation, CHU Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital, 75651 Paris, Cedex 13, France. Address e-mail to louis.puybasset{at}psl.aphp.fr.

In this study, we assessed the relationship between brain estimated specific gravity (eSG) and clinical symptoms, therapeutic intensity level, and outcome in human traumatic brain injury (TBI). Brain weight, volume, and eSG of the noncontused hemispheric areas were measured from computed tomography (CT) DICOM images on the initial (5 ± 6 h) CT of 120 patients with severe TBI. Control values were obtained from 40 healthy patients. The eSG of the noncontused hemispheric areas was significantly higher in TBI patients than in controls. eSG was higher in patients having a Marshall CT classification of 3 or 4 or a low initial Glasgow coma score. Two groups were defined according to the eSG of the noncontused hemispheric areas: less than (n = 83, 69%) or more than (n = 37, 31%) the threshold of normality (defined as 1.96 sd above normal = 1.0355 g/mL). The occurrence of mydriasis, use of osmotherapy at the scene of the accident, and therapeutic intensity level were higher in the increased eSG group. The outcome at intensive care unit discharge was worse in patients with an increased eSG although the difference was no longer significant at 1 yr. eSG determination by CT analysis might be relevant in the early management of TBI.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.