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Anesth Analg 2006;103:1250-1255
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000247965.41868.da

OBSTETRIC ANESTHESIA

The Effects of Spinal Anesthesia on QT Interval in Preeclamptic Patients

Selda Sen, MD*, Galip Ozmert, MD{dagger}, Hakan Turan, MD{dagger}, Eray Caliskan, MD{dagger}, Alper Onbasili, MD{ddagger}, and Duran Kaya, MD§

From the Departments of *Anaesthesiology and {ddagger}Cardiology, Adnan Menderes University, Aydin, Turkey; {dagger}Department of Obstetric and Gynecology, SSK Ankara Maternity and Women's Health Teaching Hospital; and §Department of Internal Medicine, Ankara University, Ankara, Turkey.

Address correspondence and reprint requests to Selda Sen, MD, Adnan Menderes Üniversitesi Tip Fakültesi, Anesteziyoloji ve Reanimasyon A.D., 09100 Aydin, Turkey. Address e-mail to drseldasen{at}yahoo.com.

In this study, we measured the effects of spinal anesthesia on the corrected QT (QTc) interval in women with severe preeclampsia. Twenty-five preeclamptic (preeclamptic group) and 25 healthy pregnant women with normal arterial blood pressure and QTc interval (control group) were enrolled in this prospective, case-controlled study. Arterial blood pressure, heart rate, and QTc interval values were obtained before (baseline value) and at 5, 10, 20, 30, 60, and 120 min after initiation of spinal anesthesia. Total ephedrine dose, time elapsed until sensory block, and Apgar scores were recorded. Prior to spinal anesthesia, QTc interval values were significantly higher in the preeclamptic group (452 ± 17.5 ms) when compared with that in controls (376 ± 21.4 ms). Although the QTc interval shortened during spinal anesthesia when compared with baseline value in the preeclamptic group (P < 0.05), it showed no significant change in the control group. In conclusion, the QTc interval may be prolonged in severe preeclamptic patients who have hypertension and hypocalcemia. Spinal anesthesia for cesarean delivery may normalize that prolonged QTc interval due to sympathetic blockade.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.