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ANALGESIA

A Single Preoperative Dose of Gabapentin (800 Milligrams) Does Not Augment Postoperative Analgesia in Patients Given Interscalene Brachial Plexus Blocks for Arthroscopic Shoulder Surgery

Frédéric Adam, MD^*, Christophe Ménigaux, MD^*, Daniel I. Sessler, MD, and Marcel Chauvin, MD

From the *Department of Anesthesia, Hôpital Ambroise Paré, Assistance Publique-Hôpitaux de Paris; Department of Outcomes Research, The Cleveland Clinic, Cleveland, Ohio; Outcomes Research Institute, University of Louisville, Louisville, KY; and Department of Anesthesia and INSERM E 332, Hôpital Ambroise Paré.

Address correspondence and reprint requests to Frédéric Adam, MD, Hôpital Ambroise Paré, Assistance Publique-Hôpitaux de Paris, 9 Ave. Charles de Gaulle, 92100 Boulogne, France. Address e-mail to frederic.adam{at}apr.ap-hop-paris.fr.

Abstract

BACKGROUND: Inadequate analgesia is common after shoulder arthroscopy. Both interscalene blocks and gabapentin are effective methods of pain management under various circumstances. We tested the hypothesis that gabapentin augments postoperative analgesia provided by interscalene brachial plexus block in patients having ambulatory arthroscopic shoulder surgery.

METHODS: Sixty patients were randomly assigned to receive oral gabapentin, 800 mg, or placebo 2 h before surgery. An interscalene brachial plexus block with 0.3 mL/kg of 0.5% ropivacaine was performed. General anesthesia was maintained with sevoflurane and included a single 1-µg/kg dose of remifentanil. Postoperative analgesia was initially provided with morphine and subsequently with ketoprofene (150 mg orally twice daily) and a combination of 400 mg acetaminophen and 30 mg dextropropoxyphene as needed. Pain scores, analgesic requirements, and side effects were assessed in the ambulatory unit and at home for 48 h.

RESULTS: Emergence from general anesthesia was similar in both groups. There were no significant differences in pain scores, first postoperative request for analgesia, or oral analgesic consumption. The incidence of side effects was comparable in both groups, except that headaches were less frequent in the gabapentin group.

CONCLUSION: A single preoperative dose of gabapentin (800 mg) does not augment postoperative analgesia in patients given interscalene brachial plexus blocks for arthroscopic shoulder surgery.

This article has been cited by other articles:

				V. K. F. Kong and M. G. Irwin Gabapentin: a multimodal perioperative drug? Br. J. Anaesth., December 1, 2007; 99(6): 775 - 786. [Abstract] [Full Text] [PDF]

				N. M. Gajraj Pregabalin: Its Pharmacology and Use in Pain Management Anesth. Analg., December 1, 2007; 105(6): 1805 - 1815. [Abstract] [Full Text] [PDF]

				F. Adam, D. I. Sessler, and M. Chauvin Single-Dose Gabapentin Does Not Augment Postoperative Analgesia in Ambulatory Arthroscopic Shoulder Surgery Anesth. Analg., July 1, 2007; 105(1): 281 - 281. [Full Text] [PDF]

				S. R. Clendenen and B. A. Harrison Single-Dose Gabapentin Does Not Augment Postoperative Analgesia in Ambulatory Arthroscopic Shoulder Surgery Anesth. Analg., July 1, 2007; 105(1): 280 - 281. [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999