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ANESTHETIC PHARMACOLOGY

The Effect of Too Much Intravenous Lidocaine on Bispectral Index

From the Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia.

Address correspondence and reprint requests to Marcel E. Durieux, MD, PhD, Department of Anesthesiology, University of Virginia Health System, Box 800710, Charlottesville, VA 22908. Address e-mail to durieux{at}virginia.edu.

Systemic local anesthetics have beneficial perioperative properties and have an anesthetic-sparing effect. To assess depth of anesthesia during lidocaine infusion, it would be important to know the effect of systemic local anesthetics on bispectral index (BIS). However, this has not been investigated. We report an inadvertent overdose of IV lidocaine in a patient monitored with BIS. BIS decreased to 0 for approximately 15 min, indicating that lidocaine and sevoflurane interact to decrease BIS.

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999