JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eberspächer, E.
Right arrow Articles by Engelhard, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eberspächer, E.
Right arrow Articles by Engelhard, K.
Related Collections
Right arrow Neuroanesthesia
Right arrow Pharmacology

Anesth Analg 2006;103:1527-1533
© 2006 International Anesthesia Research Society
doi: 10.1213/01.ane.0000247803.30582.2d

NEUROSURGICAL ANESTHESIA

The Effect of Electroencephalogram-Targeted High- and Low-Dose Propofol Infusion on Histopathological Damage After Traumatic Brain Injury in the Rat

Eva Eberspächer, DVM*, Kerstin Heimann, DVM{dagger}, Regina Hollweck, DS{ddagger}, Christian Werner, MD§, Gerhard Schneider, MD{dagger}, and Kristin Engelhard, MD§

From the *Department of Surgical and Radiological Sciences, Veterinary Medical Teaching Hospital, University of California at Davis, Davis, California; {dagger}Klinik für Anaesthesiologie; and {ddagger}Department for Medical Statistics and Epidemiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; §Klinik für Anästhesiologie, Klinikum der Johannes Gutenberg-Universität, Mainz, Germany.

Address correspondence and reprint requests to Eva Eberspächer, DVM, University of California, Veterinary Medical Teaching Hospital, Anesthesia/Critical Patient Care, One Shields Ave., Davis, CA. Address e-mail to eberspaecher{at}ucdavis.edu.

BACKGROUND: Propofol is commonly used to sedate patients after traumatic brain injury. However, the dose-dependent neuroprotective effects of propofol after head trauma are unknown. We compared histopathological damage after 6 h of electroencephalogram-targeted high- and low-dose propofol infusion in rats subjected to controlled cortical impact (CCI).

METHODS: Animals were randomly assigned to CCI/propofol with electroencephalogram burst-suppression-ratio 1%–5% (CCI/lowprop), CCI/propofol with burst-suppression-ratio 30%–40% (CCI/highprop), control group CCI/1.0 vol % halothane (CCI/halo), or sham group with halothane anesthesia (SHAM/halo). Brain slices were stained with kresyl violet (KV) and hematoxylin/eosin (HE) to evaluate lesion volume, number of eosinophilic cells, and activation of caspase-3 in the hippocampus.

RESULTS: Lesion volume (mm3) and number of eosinophilic cells in the hippocampus did not differ significantly [lesion volumes: CCI/lowprop 31.55 ± 14.66 (KV) and 53.77 ± 8.62 (HE); CCI/highprop 33.81 ± 10.57 (KV) and 52.30 ± 11.55 (HE); CCI/halo 36.42 ± 17.06 (KV) and 57.95 ± 8.49 (HE)]. Activation of caspase-3 occurred in the ipsilateral hippocampus in all CCI-groups.

CONCLUSION: Despite different levels of cortical neuronal function, there were no relevant differences in the short-term histopathological damage. These results challenge the view that the neuroprotective effect of propofol relates to the suppression of cerebral metabolic demand.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2006 by the International Anesthesia Research Society.