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Anesth Analg 2007;104:421-424
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000253668.10453.de

OBSTETRIC ANESTHESIA

Does Ondansetron or Granisetron Prevent Subarachnoid Morphine-Induced Pruritus After Cesarean Delivery?

Sahar M. Siddik-Sayyid, MD, FRCA, Marie T. Aouad, MD, Samar K. Taha, MD, Mireille S. Azar, MD, Mona A. Hakki, MD, Romeo N. Kaddoum, MD, Viviane G. Nasr, MD, Vanda G. Yazbek, MD, and Anis S. Baraka, MD, FRCA

From the Department of Anesthesiology, American University of Beirut Medical center, Beirut, Lebanon.

Address correspondence and reprint requests to Sahar Siddik-Sayyid, MD, FRCA, American University of Beirut, Department of Anesthesiology, P.O.Box 11-0236, Beirut, Lebanon. Address e-mail to ss01{at}aub.edu.lb.

BACKGROUND: We compared the efficacy of granisetron and ondansetron for the prevention of subarachnoid morphine-induced pruritus after cesarean delivery.

METHODS: The incidence of pruritus was assessed in parturients who were randomly allocated into Group G (granisetron 3 mg IV, n = 45), Group O (ondansetron 8 mg IV, n = 42), and Group S (saline IV, n = 42).

RESULTS: The incidence of pruritus was not significantly different among the 3 groups (86.6% in Group S, 83.3% in Group O, and 88% in the Group G).

CONCLUSION: Neither prophylactic ondansetron nor granisetron reduced the incidence of subarachnoid morphine-induced pruritus when compared with the saline group.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2007 by the International Anesthesia Research Society.