JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Robards, C.
Right arrow Articles by Brull, S. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Robards, C.
Right arrow Articles by Brull, S. J.
Related Collections
Right arrow Genetics
Right arrow General
Right arrow Pharmacology

Anesth Analg 2007;104:435-436
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000252462.70451.0e

GENERAL ARTICLES

The Anesthetic Implications of Crigler-Najjar Syndrome

Christopher Robards, MD, and Sorin J. Brull, MD

From the Department of Anesthesiology, Mayo Clinic College of Medicine, Mayo Clinic, Jacksonville, Flourida.

Address correspondence and reprint requests to Sorin J. Brull, MD, Mayo Clinic, JAB 4035, 4500 San Pablo Rd., Jacksonville, FL 32224, (904) 296-5688. Address e-mail to brull.sorin{at}mayo.edu.

Crigler-Najjar syndrome is a hereditary condition of unconjugated hyperbilirubinemia due to a deficiency of the enzyme, uridine diphosphate glucuronosyltransferase. Exacerbations of the disease can occur whenever there is either an increase in free serum bilirubin and/or a decrease in serum albumin. The exacerbations can lead to bilirubin encephalopathy and severe brain damage. The goal of anesthetic management in these patients is to prevent an imbalance in the serum bilirubin to serum albumin molar ratio, thereby avoiding neurologic sequelae.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2007 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2007 by the International Anesthesia Research Society.