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Anesth Analg 2007;104:847-849
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000257925.36641.9e

ANESTHETIC PHARMACOLOGY

A Comparison of Laser-Assisted Drug Delivery at Two Output Energies for Enhancing the Delivery of Topically Applied LMX-4® Cream Prior to Venipuncture

Jeffrey L. Koh, MD, MBA*{dagger}, Dale Harrison, MPH{dagger}, Veronica Swanson, MD*{dagger}, Daniel C. Norvell, PhD{ddagger}, and Darren C. Coomber, PhD§

From the Departments of *Anesthesiology and Peri-Operative Medicine and {dagger}Pediatrics, Oregon Health and Science University, Doernbecher Children’s Hospital, Portland, Oregon; {ddagger}Olympic Research, Incorporated, Lakewood, Washington; and §Norwood Abbey, Limited, Chelsea Heights, Victoria, Australia.

Address correspondence and reprint requests to Jeffrey L. Koh, MD, MBA, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd., Mail Code UHS2, Portland, OR 97239. Address e-mail to kohj{at}ohsu.edu.

BACKGROUND: Laser-assisted drug delivery (LAD) has the potential for facilitating topical anesthesia with reduced onset time.

METHODS: In this randomized, double-blind, crossover study we compared the efficacy and adverse event profile of LAD for topical anesthesia before venipuncture using two output energies (2.0 and 3.5 J/cm2).

RESULTS: Mean Visual Analog Scale pain scores were not statistically different (P = 0.57) between the low-energy (mean = 6.7) and high-energy (mean = 8.1) lasers.

CONCLUSIONS: LAD at an energy of 2.0 J/cm2 (570 mJ) is as effective, with similar adverse events, as an energy of 3.5 J/cm2 (1000 mJ) in facilitating topical anesthesia.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2007 by the International Anesthesia Research Society.