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Anesth Analg 2007;104:982-983
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000257949.46444.a8

ANALGESIA

Co-injection of Clonidine Prolongs the Anesthetic Effect of Lidocaine Skin Infiltration by a Peripheral Action

Jayant Nick Pratap, MA, MRCPCH, FRCA*, Rajesh K. Shankar, FRCA{dagger}, and Teodor Goroszeniuk, FCA RCSI*

From the *Department of Anaesthesia, Guy's & St. Thomas' NHS Foundation Trust, London, UK; and {dagger}Department of Anaesthesia, St Richard's Hospital, Royal West Sussex NHS Trust, Chichester, UK.

Address correspondence and reprint requests to Teodor Goroszeniuk, FCA RCSI, Department of Anaesthesia, Guy's Hospital, Guy's & St. Thomas' NHS Foundation Trust, St. Thomas St., London SE1 9RT, UK. Address e-mail to teogoroszeniuk{at}doctors.org.uk.

Abstract

BACKGROUND: The addition of clonidine to local anesthesia prolongs the local anesthetic action, but in humans, the contribution of a peripheral mechanism remains unclear.

METHODS: We investigated clonidine's peripheral effect in 20 healthy volunteers undergoing double-blind, subcutaneous infiltration of 0.5% lidocaine with normal saline to one forearm and then, immediately, of lidocaine with 10 µg clonidine to the contralateral arm. Pinprick sensation was tested every 15 min for 6 h.

RESULTS: Median time to return of normal sensation was 3.5 h for lidocaine alone, but at least 6 h if combined with clonidine (P < 0.001).

CONCLUSIONS: Clonidine has a significant peripheral action in enhancing duration of local anesthesia on superficial co-infiltration with lidocaine.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2007 by the International Anesthesia Research Society.