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Anesth Analg 2007;104:1023-1028
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000263285.03361.3a

CARDIOVASCULAR ANESTHESIA

Preexisting Cognitive Impairment in Patients Scheduled for Elective Coronary Artery Bypass Graft Surgery

Brendan S. Silbert, MB, BS, FANZCA*, David A. Scott, MB, BS, PhD, FANZCA*, Lisbeth A. Evered, BSc*, Matthew S. Lewis, BApp Sci (Hons), PhD*{dagger}, and Paul T. Maruff, PhD{dagger}

From the *Department of Anaesthesia, Centre for Anaesthesia and Cognitive Function, St. Vincent's Hospital; and {dagger}School of Psychological Science, La Trobe University, Melbourne, Australia.

Address correspondence to Brendan Silbert, MB, BS, FANZCA, Department of Anaesthesia, St. Vincent's Hospital, PO Box 2900, Fitzroy, Australia. Address e-mail to brendan.silbert{at}svhm.org.au.

BACKGROUND: An accurate assessment of the prevalence of cognitive impairment in patients scheduled for coronary artery bypass graft (CABG) surgery is necessary if valid assumptions regarding cognitive change are to be made. Such an assessment requires the use of a healthy control group free of cardiovascular disease.

METHODS: In a retrospective observational study, 349 patients scheduled for CABG surgery underwent neuropsychological testing. We compared the results with those from a group of 170 healthy controls without cardiovascular disease and containing more female patients who were matched for age and IQ score. Cognitive impairment was defined as test scores ≥2 sd less than the controls on two or more of the seven tests.

RESULTS: The CABG surgery patients performed significantly worse than the control group on all tests except the Grooved Pegboard test (nondominant). When analyzed by group, performance on the verbal learning test was the most impaired. Cognitive impairment was present in 122 (35%) of CABG surgery patients before their procedure. Prior myocardial infarction, age, and IQ were independent predictors of cognitive impairment.

CONCLUSIONS: Cognitive impairment is prevalent in patients presenting for CABG surgery. Impaired cognition before surgery must be considered when assessing the effects of CABG surgery on cognitive performance.




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C. W. Hogue, O. A. Selnes, and G. McKhann
Should All Patients Undergoing Cardiac Surgery Have Preoperative Psychometric Testing: A Brain Stress Test?
Anesth. Analg., May 1, 2007; 104(5): 1012 - 1014.
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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2007 by the International Anesthesia Research Society.