This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Eger, E. I. Articles by Lou, Y. Search for Related Content PubMed PubMed Citation Articles by Eger, E. I., II Articles by Lou, Y.

---

ANESTHETIC PHARMACOLOGY

Anesthetic Properties of Some Fluorinated Oxolanes and Oxetanes

Edmond I. Eger, II, MD^*, David Lemal, PhD, Michael J. Laster, DVM^*, Mark Liao, BS^*, Katarzyna Jankowska, DVM^*, Anilkumar Raghavanpillai, PhD, Anatoliy V. Popov, PhD, Yonghong Gan, PhD, and Yan Lou, MS

From the *Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143-0464; and Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755-3564.

Address correspondence to Dr. Edmond I Eger, II, Department of Anesthesia, S-455, University of California, San Francisco, California 94143-0464. Address e-mail to egere{at}anesthesia.ucsf.edu.

BACKGROUND: The search for new potent inhaled anesthetics has slowed, in large part because of the excellence of the two most recent additions, desflurane and sevoflurane. Nonetheless, neither desflurane nor sevoflurane are ideal anesthetics, desflurane causing cardiorespiratory stimulation, and sevoflurane having a slower (albeit rapid) recovery from anesthesia. Sevoflurane also can produce convulsions and postoperative agitation.

METHODS AND RESULTS: In the present report, we describe the physical and anesthetic properties of 31 cyclic ethers halogenated solely with fluorine. Although several produced anesthesia, none had solubilities that would make them better than sevoflurane. The remaining ethers were unstable or produced obvious central nervous system irritation, including convulsions.

CONCLUSIONS: We find that none of these cyclic ethers appear to provide advantages over desflurane or sevoflurane.