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Anesth Analg 2007;104:1498-1503
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000264089.72804.54

NEUROSURGICAL ANESTHESIA

Electrocerebral Silence After Intracarotid Propofol Injection Is a Function of Transit Time

Mei Wang, MPH, and Shailendra Joshi, MD

From the Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York.

Address correspondence to: Shailendra Joshi, MD, Department of Anesthesiology, P&S P Box 46, College of Physicians and Surgeons of Columbia University, 630 West 168th St., New York, NY 10032. Address e-mail to sj121{at}columbia.edu.

BACKGROUND: We hypothesized that the duration of electrocerebral (electroencephalogram, EEG) silence after bolus injection of propofol, a highly lipid soluble anesthetic drug, during transient cerebral hypoperfusion, will be directly related to the time taken by the bolus of drug to transit the cerebral circulation.

METHODS: We randomly divided 24 New Zealand White rabbits into two propofol volume groups: 0.5 and 0.8 mL groups. In each group, 12 animals received two intracarotid injections of 1% propofol: the first injection was made under normal physiological conditions and the second injection during cerebral hypoperfusion produced by bilateral carotid occlusion and IV bolus injection of adenosine and esmolol. We determined the duration of electrocerebral silence and the transit time of propofol emulsion under both cerebral circulation conditions. The transit time was measured by videomicroscopy through an implanted cranial window.

RESULTS: Cerebral hypoperfusion increased transit time with both low (2.3 ± 0.7 to 55.7 ± 21.4 s, n = 12, P < 0.0001) and high (2.2 ± 0.6 to 62.5 ± 31 s, n = 12, P < 0.0001) bolus volumes. The duration of electrocerebral silence during cerebral hypoperfusion was a function of the transit time with low (electrocerebral silence s = 152 + 2.3 x transit time, n = 12, r = 0.73, P = 0.007) and high (electrocerebral silence s = 186 + 3.2 x transit time, n = 12, r = 0.68, P = 0.02) bolus volumes.

CONCLUSION: These results suggest that manipulation of the transit time of highly lipid-soluble drugs profoundly enhances the effect site delivery.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2007 by the International Anesthesia Research Society.