JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reuben, S. S.
Right arrow Articles by Charron, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reuben, S. S.
Right arrow Articles by Charron, D.
Related Collections
Right arrow Pain Medicine
Right arrow Pain
Right arrow Pharmacology

Anesth Analg 2007;105:222-227
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000265440.98491.e2


ANALGESIA

Evaluating the Analgesic Efficacy of Administering Celecoxib as a Component of Multimodal Analgesia for Outpatient Anterior Cruciate Ligament Reconstruction Surgery

Scott S. Reuben, MD*{dagger}, Evan F. Ekman, MD{ddagger}, and Derek Charron, BS§

From the *Department of Anesthesiology, Baystate Medical Center, Springfield, Massachusetts; {dagger}Department of Anesthesiology and Pain Medicine, Tufts University School of Medicine, Boston, Massachusetts; {ddagger}Department of Orthopaedic Surgery, Parkridge Surgery Center, Columbia, South Carolina; and §Department of Pharmacy, Baystate Medical Center, Springfield, Massachusetts.

Address correspondence and reprint requests to Scott S. Reuben, MD, Department of Anesthesiology, Baystate Medical Center, 759 Chestnut St., Springfield, MA 01199. Address e-mail to scott.reuben{at}bhs.org.

Abstract

BACKGROUND: Cyclooxygenase-2 inhibitors may play an important role in multimodal management of pain after orthopedic surgery. We examined the analgesic efficacy of administering celecoxib as a component of a multimodal analgesic regimen for outpatient anterior cruciate ligament (ACL) surgery.

METHODS: Two-hundred consecutive patients were randomized to receive acetaminophen 1000 mg and either celecoxib 400 mg or placebo 1–2 h before ACL surgery. All patients received intraarticular analgesics (bupivacaine, clonidine, and morphine) and had an external cooling system applied to the operative knee. After discharge, patients were instructed to take acetaminophen 1000 mg every 6 h and either celecoxib 200 mg every 12 h or matching placebo for the first 14 days postoperatively. Oxycodone 5–10 mg was available for rescue analgesia.

RESULTS: Patients in the celecoxib group were more likely to experience less pain in the recovery room (P < 0.01) and require less opioids (P < 0.001) for postoperative analgesia. These patients reported a lower incidence of postoperative nausea and vomiting (P < 0.05) and were discharged home earlier (P < 0.05). While at home, patients in the celecoxib group reported lower pain scores both at rest (P < 0.05) and with movement (P < 0.01), and used less oxycodone at all postoperative time intervals.

CONCLUSIONS: The perioperative administration of celecoxib decreases postoperative pain, opioid use, postoperative nausea and vomiting, and recovery room length of stay. These results support the use of celecoxib as a component of a preventive multimodal analgesic technique for ACL surgery.




This article has been cited by other articles:


Home page
Anesth. Analg.Home page
S. L. Shafer
NOTICE OF RETRACTION
Anesth. Analg., April 1, 2009; 108(4): 1350 - 1350.
[Full Text] [PDF]


Home page
Foot Ankle SpecHome page
I. Turan, H. Assareh, C. Rolf, and J. G. Jakobsson
Clinical Research: Etoricoxib, Paracetamol, and Dextropropoxyphene for Postoperative Pain Management: A Questionnaire Survey of Consumption of Take-Home Medication After Elective Hallux Valgus Surgery
Foot & Ankle Specialist, April 1, 2008; 1(2): 88 - 92.
[Abstract] [PDF]


Home page
Anesth. Analg.Home page
S. S. Reuben, A. Buvenandran, B. Katz, and J. S. Kroin
A Prospective Randomized Trial on the Role of Perioperative Celecoxib Administration for Total Knee Arthroplasty: Improving Clinical Outcomes
Anesth. Analg., April 1, 2008; 106(4): 1258 - 1264.
[Abstract] [Full Text] [PDF]


Home page
Anesth. Analg.Home page
S. S. Liu and C. L. Wu
The Effect of Analgesic Technique on Postoperative Patient-Reported Outcomes Including Analgesia: A Systematic Review
Anesth. Analg., September 1, 2007; 105(3): 789 - 808.
[Abstract] [Full Text] [PDF]


Home page
Anesth. Analg.Home page
S. B. Goodman
Multimodal Analgesia for Orthopedic Procedures
Anesth. Analg., July 1, 2007; 105(1): 19 - 20.
[Full Text] [PDF]




Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2007 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2007 by the International Anesthesia Research Society.