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Anesth Analg 2007;105:251-255
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000252929.88517.b0

ANALGESIA

The Antipruritic and Antiemetic Effects of Epidural Droperidol: A Study of Three Methods of Administration

In Ho Lee, MD*, and Il Ok Lee, MD{dagger}

From the *Department of Anesthesiology, Cheil General Hospital, and Women’s Healthcare Center, Kwandong University College of Medicine, Seoul, Korea; and {dagger}Department of Anesthesiology, Korea University College of Medicine, Seoul, Korea.

Address correspondence and reprint requests to Il Ok Lee, MD, Department of Anesthesiology, Guro Hospital, Guro gu Gurodong gil 97, Korea University College of Medicine, Seoul, South Korea. Address e-mail to iloklee{at}korea.ac.kr.

Abstract

BACKGROUND: In this study, we compared rates of postoperative nausea and vomiting (PONV) and pruritus after using different protocols for administering epidural droperidol.

METHODS: Using the same dose of droperidol, we evaluated the effectiveness of three different methods of administration (single, continuous, and combined) on the frequency of PONV and pruritus induced by continuous infusion of epidural fentanyl for 48 h postoperatively. One hundred sixty ASA physical status I and II patients who underwent surgical resection for colorectal cancer under general anesthesia combined with epidural anesthesia were randomly allocated into four groups: (a) control group (no droperidol), (b) single injection group (droperidol 2.5 mg), (c) continuous group (droperidol 1.25 mg/day) and (d) combined single (droperidol 1.25 mg) and continuous (droperidol 0.625 mg/day) group.

RESULTS: Pruritus and PONV were significantly less frequent in all droperidol groups, when compared with the control group (P < 0.05). The incidence and the incidence over time of PONV were similar among all groups who received epidural droperidol.

CONCLUSION: Epidural droperidol is effective for reducing pruritus and PONV, regardless of the method of administration.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2007 by the International Anesthesia Research Society.