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Anesth Analg 2007;105:381-385
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000261277.65343.4e

ANESTHETIC PHARMACOLOGY

Mouse Chromosome 7 Harbors a Quantitative Trait Locus for Isoflurane Minimum Alveolar Concentration

Michael Cascio, BS*, Yilei Xing, MD*, Diane Gong, PharmD{dagger}, John Popovich, BS*, Edmond I. Eger, II, MD*, Saunak Sen, PhD{ddagger}, Gary Peltz, MD, PhD§, and James M. Sonner, MD*

From the *Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA; {dagger}The Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin; {ddagger}Department of Biostatistics, University of California, San Francisco, CA; and §Department of Genetics and Genomics, Roche Palo Alto, Palo Alto, CA.

Address correspondence to Dr. Sonner, Department of Anesthesia and Perioperative Care, S-455i, University of California, San Francisco, CA 94143-0464. Address e-mail to sonnerj{at}anesthesia.ucsf.edu.

BACKGROUND: The minimum alveolar concentration (MAC) of isoflurane is a quantitative trait because it varies continuously in a population. The location on the genome of genes or other genetic elements controlling quantiative traits is called quantitative trait loci (QTLs). In this study we sought to detect a quantitative trait locus underlying isoflurane MAC in mice.

METHODS: To accomplish this, two inbred mouse strains differing in isoflurane MAC, the C57BL/6J and LP/J mouse strains, were bred through two generations to produce genetic recombination. These animals were genotyped for microsatellite markers. We also applied an independent, computational method for identifying QTL-regulating differences in isoflurane MAC. In this approach, the isoflurane MAC was measured in a panel of 19 inbred strains, and computationally searched for genomic intervals where the pattern of genetic variation, based on single nucleotide polymorphisms, correlated with the differences in isoflurane MAC among inbred strains.

RESULTS AND CONCLUSIONS: Both methods of genetic analysis identified a QTL for isoflurane MAC that was located on the proximal part of mouse chromosome 7.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2007 by the International Anesthesia Research Society.