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Anesth Analg 2007;105:832-837
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000275201.64587.1f

ANALGESIA

Reflex Sympathetic Activity After Intravenous Administration of Midazolam in Anesthetized Cats

Ryoji Iida, MD, PhD*, Ken-ichi Iwasaki, MD, PhD{dagger}, Jitsu Kato, MD, PhD*, Shigeru Saeki, MD, PhD*, and Setsuro Ogawa, MD, PhD*

From the Departments of *Anesthesiology and {dagger}Hygiene and Space Medicine, Nihon University School of Medicine, Tokyo, Japan.

Address correspondence and reprint requests to Ryoji Iida, MD, PhD, Department of Anesthesiology, Nihon University School of Medicine, 30-1, Oyaguchi-Kamicho, Itabashi-Ku, Tokyo 173-8610, Japan. Address e-mail to ryoiida{at}med.nihon-u.ac.jp.

Abstract

BACKGROUND: Although intrathecal midazolam has been reported to produce antinociceptive effects mediated by {gamma}-aminobutyric acid type A-benzodiazepine receptor complexes in the spinal cord, the effects of systemic midazolam on nociception remain unclear. We performed this study to examine the effects of IV-administered midazolam on somatosympathetic A{delta} and C reflex discharges in brain-intact cats and decerebrate cats (with transection at midbrain level).

METHODS: Somatosympathetic A{delta}and C reflexes were elicited in the inferior cardiac sympathetic nerve by electrical stimulation of myelinated (A{delta}) and unmyelinated (C) afferent fibers of the superficial peroneal nerve in 28 mature cats. After control somatosympathetic reflex responses were obtained, midazolam was administered IV to four groups of randomly allocated cats as follows: brain-intact cats at a dose of 0.03 mg/kg, brain-intact cats at a dose of 0.1 mg/kg, brain-intact cats at a dose of 0.5 mg/kg, and decerebrate cats at a dose of 0.1 mg/kg.

RESULTS: C reflex discharges were significantly augmented at the dose of 0.03 mg/kg and significantly depressed at the dose of 0.1 and 0.5 mg/kg in brain-intact cats. C reflex discharges were also significantly depressed at the dose of 0.1 mg/kg in decerebrate cats.

CONCLUSIONS: We have demonstrated that IV midazolam produces dose-related effects on somatosympathetic reflex discharges. The clinical implication of these findings is that the effect of midazolam on nociception depends on its dosage. It also appears that the infra-midbrain region plays a major role in mediating the depressive effects of midazolam on somatosympathetic C reflex discharges.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2007 by the International Anesthesia Research Society.