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Anesth Analg 2007; 105:1379-1384
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000282835.10607.b8
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CRITICAL CARE AND TRAUMA

The Effects of Different Dobutamine Infusion Rates on Hypercapnic Depression of Diaphragmatic Contractility in Pentobarbital-Anesthetized Dogs

Yoshitaka Fujii, MD, and Aki Uemura, MD

From the Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan.

Address correspondence and reprint requests to Yoshitaka Fujii, MD, First Department of Anesthesiology, Toho University School of Medicine, 6-11-1 Ohmori-Nishi, Ohta-ku, Tokyo 143-8541, Japan. Address e-mail to yfujii{at}med.toho-u.ac.jp.

BACKGROUND: Previously, we demonstrated that dobutamine was more effective than dopamine for the improvement of diaphragmatic contractility during hypercapnia. Here, we studied the effects of different dobutamine infusion rates on hypercapnic depression of diaphragmatic contractility in pentobarbital-anesthetized dogs.

METHODS: Animals were divided into four groups of six each. In each group, hypercapnia (80–90 mm Hg) was produced by adding 10% CO2 to inspired gas. When hypercapnia was established, group Dob 0 received no study drug; group Dob 5 was induced with dobutamine 5 µg · kg–1 · min–1; group Dob 10 was induced with dobutamine 10 µg · kg–1 · min–1; group Dob 15 was induced with dobutamine 15 µg · kg–1 · min–1. Study drugs were administered IV for 60 min. Diaphragmatic contractility was assessed by measurement of transdiaphragmatic pressure (Pdi).

RESULTS: In the presence of hypercapnia, in each group, Pdi at low-frequency (20 Hz) and high-frequency (100 Hz) stimulation decreased from baseline (P < 0.05). In group Dob 0, Pdi to each stimulus did not change from hypercapnia-induced values. In groups Dob 5, Dob 10 and Dob 15, during the study drug administration, Pdi at both stimuli increased from hypercapnia-induced values (P < 0.05). There was a significant positive correlation between dobutamine infusion rates and Pdi at both stimuli (P = 0.0001).

CONCLUSION: Dobutamine effectively improves hypercapnic depression of diaphragmatic contractility in an infusion rate-dependent manner in pentobarbital-anesthetized dogs.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2007 by the International Anesthesia Research Society.