JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

Anesth Analg 2007; 105:1474-1481
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000287270.35176.3e
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tomic, M. A.
Right arrow Articles by Boskovic, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tomic, M. A.
Right arrow Articles by Boskovic, B.
Related Collections
Right arrow Pain Medicine
Right arrow Preclinical Pharmacology
Right arrow Pain
Right arrow Pharmacology

PAIN MECHANISMS

The Involvement of Peripheral {alpha}2-Adrenoceptors in the Antihyperalgesic Effect of Oxcarbazepine in a Rat Model of Inflammatory Pain

Maja A. Tomic, BPharm, MSc*, Sonja M. Vuckovic, MD, PhD{dagger}, Radica M. Stepanovic-Petrovic, BPharm, PhD*, Nenad D. Ugresic, BPharm, PhD*, Sonja Lj Paranos, BPharm*, Milica S Prostran, MD, PhD{dagger}, and Bogdan Boskovic, BPharm, MD, PhD{ddagger}

From the *Department of Pharmacology, Faculty of Pharmacy, {dagger}Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; and {ddagger}Medical Military Academy, Belgrade, Serbia.

Address correspondence and reprint requests to Maja A. Tomic, BPharm, MSc, Department of Pharmacology, Faculty of Pharmacy, Vojvode Stepe 450, POB 146, 11221 Belgrade, Serbia. Address e-mail to majat{at}pharmacy.bg.ac.yu.

Abstract

BACKGROUND: We studied whether peripheral {alpha}2-adrenergic receptors are involved in the antihyperalgesic effects of oxcarbazepine by examining the effects of yohimbine (selective {alpha}2-adrenoceptor antagonist), BRL 44408 (selective {alpha}2A-adrenoceptor antagonist), MK-912 (selective {alpha}2C-adrenoceptor antagonist), and clonidine ({alpha}2-adrenoceptor agonist) on the antihyperalgesic effect of oxcarbazepine in the rat model of inflammatory pain.

METHODS: Rats were intraplantarly (i.pl.) injected with the proinflammatory compound concanavalin A (Con A). A paw-pressure test was used to determine: 1) the development of hyperalgesia induced by Con A; 2) the effects of oxcarbazepine (i.pl.) on Con A-induced hyperalgesia; and 3) the effects of i.pl. yohimbine, BRL 44408, MK-912 and clonidine on the oxcarbazepine antihyperalgesia.

RESULTS: Both oxcarbazepine (1000–3000 nmol/paw; i.pl.) and clonidine (1.9–7.5 nmol/paw; i.pl.) produced a significant dose-dependent reduction of the paw inflammatory hyperalgesia induced by Con A. Yohimbine (260 and 520 nmol/paw; i.pl.), BRL 44408 (100 and 200 nmol/paw; i.pl.) and MK-912 (10 and 20 nmol/paw; i.pl.) significantly depressed the antihyperalgesic effects of oxcarbazepine (2000 nmol/paw; i.pl.) in a dose-dependent manner. The effects of antagonists were due to local effects since they were not observed after administration into the contralateral hindpaw. Oxcarbazepine and clonidine administered jointly in fixed-dose fractions of the ED50 (1/4, 1/2, and 3/4) caused significant and dose-dependent reduction of hyperalgesia induced by Con A. Isobolographic analysis revealed an additive antihyperalgesic effect.

CONCLUSIONS: Our results indicate that the peripheral {alpha}2A and {alpha}2C adrenoceptors could be involved in the antihyperalgesic effects of oxcarbazepine in a rat model of inflammatory hyperalgesia.




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
R. M. Stepanovic-Petrovic, M. A. Tomic, S. M. Vuckovic, S. Paranos, N. D. Ugresic, M. S. Prostran, S. Milovanovic, and B. Boskovic
The Antinociceptive Effects of Anticonvulsants in a Mouse Visceral Pain Model
Anesth. Analg., June 1, 2008; 106(6): 1897 - 1903.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2007 by the International Anesthesia Research Society.