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Anesth Analg 2007; 105:1805-1815
© 2007 International Anesthesia Research Society
doi: 10.1213/01.ane.0000287643.13410.5e
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ANALGESIA

Pregabalin: Its Pharmacology and Use in Pain Management

Noor M. Gajraj, MD, FRCA, DABPM

From the Texas Anodyne Research Institute and Sherman Pain Care, Texas.

Address correspondence and reprint requests to Noor M. Gajraj, MD, FRCA, DABPM, 1111 Gallagher Dr., Sherman, TX 75090. Address e-mail to noorgajraj{at}aol.com.

Abstract

Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory neurotransmitter {gamma}-aminobutyric acid. It is an {alpha}2-{delta} ({alpha}2-{delta}) ligand that has analgesic, anticonvulsant, anxiolytic, and sleep-modulating activities. Pregabalin binds potently to the {alpha}2-{delta} subunit of calcium channels, resulting in a reduction in the release of several neurotransmitters, including glutamate, noradrenaline, serotonin, dopamine, and substance P. In this review, I will discuss the pharmacology of pregabalin and available efficacy studies in pain management. This review will focus on the advances in pregabalin pharmacology since my previous review in 2005.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2007 by the International Anesthesia Research Society.