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Anesth Analg 2008; 106:309-312
© 2008 International Anesthesia Research Society
doi: 10.1213/01.ane.0000287815.32869.2a
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ANALGESIA

A Comparative Study of the Analgesic Effect of Patient-Controlled Morphine, Pethidine, and Tramadol for Postoperative Pain Management After Abdominal Hysterectomy

Hakki Unlugenc, MD*, Mehmet Ali Vardar, MD{dagger}, and Sibel Tetiker, MD*

From the Departments of *Anaesthesiology, and {dagger}Gynecology and Obstetric, Cukurova University Faculty of Medicine, Adana, Turkey.

Address correspondence and reprint requests to Dr. Hakki Unlugenc, Department of Anaesthesiology, Cukurova University Faculty of Medicine, 01330 Adana, Turkey. Address e-mail to unlugenc{at}cu.edu.tr.

Abstract

We designed this prospective, randomized, double-blind study to compare the analgesic effectiveness and side effects of IV patient-controlled morphine, pethidine, and tramadol for postoperative pain management. One-hundred-twenty-six ASA physical status I or II patients undergoing abdominal hysterectomy were randomly allocated to receive IV-patient controlled morphine (M), pethidine (P), or tramadol (T) for postoperative analgesia. The cumulative analgesic consumption over 24 h was 25.7 ± 9.5 mg for morphine, 266 ± 90 mg for pethidine, and 320 ± 10 mg for tramadol. The average supplementary fentanyl dose used was significantly higher in group T than in groups M and P (P < 0.05). In conclusion, morphine, pethidine, and tramadol resulted in equivalent pain scores and side effects, but tramadol group T required more rescue analgesic doses of fentanyl.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2008 by the International Anesthesia Research Society.