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ANALGESIA

The Differential Effects of Bupivacaine and Lidocaine on Prostaglandin E₂ Release, Cyclooxygenase Gene Expression and Pain in a Clinical Pain Model

Sharon M. Gordon, DDS, MPH, PhD^*, Brian P. Chuang, DMD, MS, Xiao Min Wang, MD, PhD, May A. Hamza, MD^¶, Janet S. Rowan, RN, Jaime S. Brahim, DDS, MS^||, and Raymond A. Dionne, DDS, PhD

From the *University of Maryland, School of Dentistry, Baltimore, Maryland; Practice of Endodontics, Boston, Massachusetts; National Institute of Nursing Research; Department of Nursing, Clinical Research Center; ||National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland; and ¶Department of Pharmacology, Faculty of Medicine, Ain Shams University, Cairo Egypt.

Address correspondence and reprint requests to Dr. Sharon M. Gordon, University of MD, School of Dentistry, Baltimore, MD. Address e-mail to SGordon{at}umaryland.edu.

Abstract

BACKGROUND: In addition to blocking nociceptive input from surgical sites, long-acting local anesthetics might directly modulate inflammation. In the present study, we describe the proinflammatory effects of bupivacaine on local prostaglandin E₂ (PGE₂) production and cyclooxygenase (COX) gene expression that increases postoperative pain in human subjects.

METHODS: Subjects (n = 114) undergoing extraction of impacted third molars received either 2% lidocaine or 0.5% bupivacaine before surgery and either rofecoxib 50 mg or placebo orally 90 min before surgery and for the following 48 h. Oral mucosal biopsies were taken before surgery and 48 h after surgery. After extraction, a microdialysis probe was placed at the surgical site for PGE₂ and thromboxane B₂ (TXB₂) measurements.

RESULTS: The bupivacaine/rofecoxib group reported significantly less pain, as assessed by a visual analog scale, compared with the other three treatment groups over the first 4 h. However, the bupivacaine/placebo group reported significantly more pain at 24 h and PGE₂ levels during the first 4 h were significantly higher than the other three treatment groups. Moreover, bupivacaine significantly increased COX-2 gene expression at 48 h as compared with the lidocaine/placebo group. Thromboxane levels were not significantly affected by any of the treatments, indicating that the effects seen were attributable to inhibition of COX-2, but not COX-1.

CONCLUSIONS: These results suggest that bupivacaine stimulates COX-2 gene expression after tissue injury, which is associated with higher PGE₂ production and pain after the local anesthetic effect dissipates.

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999