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Anesth Analg 2008; 106:650-653
© 2008 International Anesthesia Research Society
doi: 10.1213/ane.0b013e31815efaba
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PAIN MECHANISMS

The Effect of Pentoxifylline on Existing Hypersensitivity in a Rat Model of Neuropathy

Jian Liu, MD, Weiyan Li, MD, Juan Zhu, MD, Jing Zhang, MS, Xiaomei Feng, MD, Ren Guan, MD, and Jianguo Xu, MD

From the Department of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, People's Republic of China.

Address correspondence and reprint requests to Jian Liu, MD, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, People's Republic of China. Address e-mail to liuj_7610{at}msn.com.

Abstract

BACKGROUND: Using a rat L5 spinal nerve transection model we previously showed that pentoxifylline prevents hyperalgesia through antiinflammation in the prefrontal brain. In this study, we examined efficacy when applied after injury.

METHODS: We examined the effect of pentoxifylline on existing mechanical allodynia, observing glial activation and proinflammatory cytokine expression in the lumbar spinal cord, when given 7 days after L5 spinal nerve transection.

RESULTS: There was no effect from pentoxifylline on existing hypersensitivity, glial activation, and cytokine expression when applied after L5 spinal nerve transection.

CONCLUSION: Pentoxifylline administered intraperitoneally on day 7 postsurgery failed to alleviate existing hypersensitivity, or reduce glial activation and cytokine expression.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2008 by the International Anesthesia Research Society.