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TECHNOLOGY, COMPUTING, AND SIMULATION

Interactive Web Simulation for Propofol and Fospropofol, a New Propofol Prodrug

From the Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida.

Address correspondence and reprint requests to Sinan Yavas, MD, Department of Anesthesiology, University of Florida College of Medicine, PO Box 100254, Gainesville, FL 32610-0254. Address e-mail to syavas{at}anest.ufl.edu.

Using pharmacokinetic and pharmacodynamic data published in the scientific literature, we have developed interactive on-line simulations to model administration of propofol and fospropofol, a new water-soluble prodrug formulation of propofol. The prodrug formulation of fospropofol leads to a delayed onset to peak concentrations of propofol. A comparison simulation that overlays administration of fospropofol and propofol allows clinicians to understand the differences of administering fospropofol and traditional propofol. The simulations have the added advantage of allowing for differences among patients documented in test studies and the use of different models.