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Anesth Analg 2008; 106:1784-1786
© 2008 International Anesthesia Research Society
doi: 10.1213/ane.0b013e318172fafc
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ANESTHETIC PHARMACOLOGY

Dexmedetomidine Sedation Leading to Refractory Cardiogenic Shock

Tina C. Sichrovsky, MD, Suneet Mittal, MD, and Jonathan S. Steinberg, MD

From the St. Luke's-Roosevelt Hospital Center/Columbia University, New York City, New York.

Address correspondence and reprint requests to Tina C. Sichrovsky, MD, St. Luke's-Roosevelt Hospital Center/Columbia University, 1111, Amsterdam Ave., New York City, NY 10025. Address e-mail to Tina.sichrovsky{at}gmx.net.

Dexmedetomidine is frequently used for deep sedation during electrophysiology procedures. We report a case where, presumably, the use of dexmedetomidine resulted in a patient's death. The patient developed unexplained and refractory cardiogenic shock and could not be resuscitated. Autopsy failed to demonstrate any abnormality or cause of death. We postulate that, in certain susceptible individuals, dexmedetomidine may lead to terminal complications. We therefore urge caution about using dexmedetomidine in the electrophysiology laboratory.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2008 by the International Anesthesia Research Society.