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Anesth Analg 2008; 107:102-106
© 2008 International Anesthesia Research Society
doi: 10.1213/ane.0b013e318173287a
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ANESTHETIC PHARMACOLOGY

Propofol Sedation Is Reduced by {Delta}9-Tetrahydrocannabinol in Mice

Philipp-Alexander Brand, MD*, Andrea Paris, MD*, Berthold Bein, MD, DEAA*, Patrick Meybohm, MD*, Jens Scholz, MD*, Henning Ohnesorge, MD*, and Peter H. Tonner, MD{dagger}

From the *Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany; and {dagger}Department of Anaesthesiology and Intensive Care Medicine, Klinikum Links der Weser, Bremen, Germany.

Address correspondence and reprint requests to Dr. Philipp-Alexander Brand, Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Germany, Schwanenweg 21, D-24105 Kiel, Germany. Address e-mail to pabrand{at}anaesthesie.uni-kiel.de.

BACKGROUND: {Delta}9-Tetrahydrocannabinol ({Delta}9-THC) induces analgesic effects and alterations of alertness. It has been reported that propofol increases endocannabinoid levels in the brain, but the effects of {Delta}9-THC on propofol sedation remain unclear. Our aim was to characterize the interaction between {Delta}9-THC and propofol in terms of sedation and analgesia.

METHODS: Sedation was monitored by a rota-rod and analgesia by tail-flick latencies. Twenty mice received intraperitoneal injections of 50 mg/kg {Delta}9-THC with 50, 75 and 100 mg/kg propofol after baseline values were established for each drug. Control experiments were performed with {Delta}9-THC and thiopental or Intralipid.

RESULTS: Injection of 50 mg/kg propofol caused a rapid onset of sedation with a minimum of 24 s on the rota-rod. Fifty mg/kg {Delta}9-THC alone had no sedative effects. Administration of {Delta}9-THC significantly reduced the sedative effect of propofol to at least 60 s on the rota-rod (P < 0.001). After increasing the propofol dose to 100 mg/kg in the presence of {Delta}9-THC, sedation was re-established with 27 s on the rota-rod. Thiopental sedation was significantly reduced (P < 0.01) in the presence of {Delta}9-THC.

CONCLUSION: The results indicate a dose-dependent antagonistic interaction between {Delta}9-THC and propofol, and also between {Delta}9-THC and thiopental.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2008 by the International Anesthesia Research Society.