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Anesth Analg 2008; 107:167-170
© 2008 International Anesthesia Research Society
doi: 10.1213/ane.0b013e3181732dc2
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CRITICAL CARE AND TRAUMA

The Efficacy of Dexmedetomidine in Patients with Noninvasive Ventilation: A Preliminary Study

Shinji Akada, MD, PhD, Shinhiro Takeda, MD, PhD, Yuko Yoshida, MD, Keiko Nakazato, MD, Masaki Mori, MD, Takashi Hongo, MD, PhD, Keiji Tanaka, MD, PhD, and Atsuhiro Sakamoto, MD, PhD

From the Department of Anesthesiology and Intensive Care, Nippon Medical School, Tokyo, Japan.

Address correspondence and reprint requests to Shinhiro Takeda, Department of Anesthesiology and Intensive Care, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. Address e-mail to shinhiro{at}nms.ac.jp.

BACKGROUND: Agitation is associated with failure of noninvasive ventilation (NIV). We investigated the effect of dexmedetomidine in patients with NIV.

METHODS: This was a prospective clinical investigation in an intensive care unit. Dexmedetomidine was infused in 10 patients in whom NIV was difficult because of agitation.

RESULTS: Ramsay and Richmond Agitation-Sedation Scale scores were maintained at 2.94 ± 0.94 and –1.23 ± 1.30, respectively. All patients were successfully weaned from NIV, and the respiratory state was not worsened.

CONCLUSION: This study shows that dexmedetomidine is an effective sedative drug for patients with NIV.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2008 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2008 by the International Anesthesia Research Society.