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Anesth Analg 2008; 107:201-214
© 2008 International Anesthesia Research Society
doi: 10.1213/ane.0b013e31817326a5
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NEUROSURGICAL ANESTHESIOLOGY

Gender and the Injured Brain

Kamila Vagnerova, MD, Ines P. Koerner, MD, PhD, and Patricia D. Hurn, PhD

From the Department of Anesthesiology and Peri-Operative Medicine, Oregon Health and Science University, Portland, Oregon.

Address correspondence and reprint requests to Patricia D. Hurn, PhD, Department of Anesthesiology and Peri-Operative Medicine, OHSU, 3181 SW Sam Jackson Park Road UHS-2, 97239, Portland, OR. Address e-mail to hurnp{at}ohsu.edu.

Abstract

Anesthesiologists are frequently confronted with patients who are at risk for neurological complications due to perioperative stroke or prior traumatic brain injury. In this review, we address the growing and fascinating body of data that suggests gender and sex steroids influence the pathophysiology of injury and outcome for these patients. Cerebral ischemia, traumatic brain injury, and epilepsy are reviewed in the context of potential sex differences in mechanisms and outcomes of brain injury and the role of estrogen, progesterone, and androgens in shaping these processes. Lastly, implications for current and future perioperative and intensive care are identified.




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 Anesth. Analg.Home page
K. Gelb and A. W. Gelb
Sex and Gender in the Perioperative Period: Wake Up to Reality
Anesth. Analg., July 1, 2008; 107(1): 1 - 3.
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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2008 by the International Anesthesia Research Society.