This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Kozek-Langenecker, S. A. Articles by Van der Linden, P. Search for Related Content PubMed PubMed Citation Articles by Kozek-Langenecker, S. A. Articles by Van der Linden, P. Related Collections Cardiovascular Blood Coagulation

---

CARDIOVASCULAR ANESTHESIOLOGY

The Effects of Hydroxyethyl Starch 130/0.4 (6%) on Blood Loss and Use of Blood Products in Major Surgery: A Pooled Analysis of Randomized Clinical Trials

Sibylle A. Kozek-Langenecker^*, Cornelius Jungheinrich^**, Wilhelm Sauermann, and Philippe Van der Linden

From the *Department of Anesthesiology, General Intensive Care and Pain Control, Vienna Medical University, Vienna, Austria; **Medical Affairs, Fresenius Kabi, Bad Homburg, Germany; DATAMAP GmbH (Biostatistics Institute), Freiburg, Germany; and Department of Anesthesiology, CHU Brugmann-HUDERF, Brussels, Belgium.

Abstract

BACKGROUND: The effects of different types of hydroxylethyl starch (HES) on blood coagulation closely depend on their physicochemical properties. HES with lower molar substitution and a lower in vivo molecular weight interferes relatively little with hemostasis and therefore results in lower perioperative blood losses and red blood cell (RBC) transfusion. To test this hypothesis, we analyzed pooled data from all available studies in major surgery comparing 6% HES 130/0.4 and 6% HES 200/0.5 from waxy maize starch.

METHODS: Estimated blood loss, drainage loss, calculated blood loss, transfused blood product volumes, and coagulation variables were examined for 24 h after the start of surgery. Groups were compared using analysis of variance, evaluating several covariates.

RESULTS: Four-hundred-forty-nine patients from seven clinical trials were analyzed, 228 received HES 130/0.4, and 221 received HES 200/0.5. For HES 130/0.4 patients, when compared to HES 200/0.5 patients, the estimated blood loss was reduced by 404 mL [P = 0.006], drainage loss was 272 mL less [P = 0.009], and calculated RBC loss was 149 mL less [P = 0.003]. RBC transfusion volumes were also lower for HES 130/0.4 by 137 mL [P = 0.004]. In the early postoperative phase, HES 130/0.4 was found to exert significantly less effect on measures of coagulation, especially activated partial thromboplastin time and von Willebrand factor (antigen and ristocetin cofactor), than HES 200/0.5.

CONCLUSIONS: Blood loss and transfusion requirements can be significantly reduced in major surgery when using third generation HES 130/0.4 (Voluven®) compared to second generation waxy maize starch HES 200/0.5. Since HES 130/0.4 and HES 200/0.5 were found similar regarding volume efficacy in other studies, HES 130/0.4 is recommended in this clinical setting.

This article has been cited by other articles:

				I. Maquoi, V. Bonhomme, J. D. Born, M.-F. Dresse, E. Ronge-Collard, J.-M. Minon, and P. Hans Perioperative Management of a Child with von Willebrand Disease Undergoing Surgical Repair of Craniosynostosis: Looking at Unusual Targets Anesth. Analg., September 1, 2009; 109(3): 720 - 724. [Abstract] [Full Text] [PDF]

				J. Boldt Modern Rapidly Degradable Hydroxyethyl Starches: Current Concepts Anesth. Analg., May 1, 2009; 108(5): 1574 - 1582. [Abstract] [Full Text] [PDF]

				C. Hartog, F. Brunkhorst, and K. Reinhart Hydroxyethyl Starch 130/0.4 and Surgical Blood Loss Anesth. Analg., February 1, 2009; 108(2): 672 - 672. [Full Text] [PDF]

				S. A. Kozek-Langenecker, C. Jungheinrich, W. Sauermann, and P. van der Linden Hydroxyethyl Starch 130/0.4 and Surgical Blood Loss Anesth. Analg., February 1, 2009; 108(2): 672 - 673. [Full Text] [PDF]