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Anesth Analg 2008; 107:652-660
© 2008 International Anesthesia Research Society
doi: 10.1213/ane.0b013e31817e66d4
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ANALGESIA

A Multiple-Day Regimen of Parecoxib Sodium 20 mg Twice Daily Provides Pain Relief After Total Hip Arthroplasty

Eugene R. Viscusi, MD*, Joseph S. Gimbel, MD{dagger}, Andreas M. Halder, MD, PhD{ddagger}, Michael Snabes, MD, PhD§, Mark T. Brown, MD||, and Kenneth M. Verburg, PhD||

From the *Department of Anesthesiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania; {dagger}Arizona Research Center, Phoenix, Arizona; {ddagger}Klinik für Endoprothetik, Waldhausstrasse, Sommerfeld, Germany; §Pfizer Global Research and Development, Skokie, Illinois; and ||Pfizer Global Research and Development, New London, Connecticut.

Address correspondence and reprint requests to Eugene R. Viscusi, MD, Department of Anesthesiology, Acute Pain Management, Jefferson Medical College of Thomas Jefferson University, 111 S. 11th St., Suite G-8490, Philadelphia, PA 19107. Address e-mail to Eugene.viscusi{at}jefferson.edu.

Abstract

BACKGROUND: This multicenter, multiple-dose, randomized, double-blind, parallel-group study compared the analgesic efficacy and safety of two dosing regimens of parecoxib sodium (parecoxib) versus placebo after total hip arthroplasty.

METHODS: On study Day 1, 490 patients received a postoperative initial loading dose of IV parecoxib 40 mg, followed by a re-dose of parecoxib 20 mg in 484 of 490 patients. Subsequently, 479 randomized patients received double-blind treatment with parecoxib 20 mg bid (n = 159), parecoxib 20 mg qd (n = 159) followed by placebo, or placebo (n = 161) on Day 2.

RESULTS: Patients treated with parecoxib 20 mg bid reported significantly lower summed pain intensity over 24 h (SPI-24) scores and improved patients’ global evaluation of study medication (PGESM) ratings compared with placebo-treated patients on Days 2 to 5 (P < 0.05). For patients treated with parecoxib 20 mg qd, SPI-24 scores were significantly lower on Days 3 and 4 (P < 0.05), and PGESM ratings significantly improved on Day 5 compared with placebo. The incidence of adverse events was similar in all treatment groups with the exception of fever, vomiting and impaired concentration, which were significantly more common in the placebo group compared with one or other of the parecoxib treatment groups (P < 0.05).

CONCLUSION: Multiple-day administration of parecoxib 20 mg once or twice daily is effective and generally well tolerated after total hip arthroplasty.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2008 by the International Anesthesia Research Society.