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ANALGESIA

Continuous Low-Dose Ketamine Improves the Analgesic Effects of Fentanyl Patient-Controlled Analgesia After Cervical Spine Surgery

Masanori Yamauchi, MD, PhD^*, Makoto Asano, MD, PhD, Masanori Watanabe, MD^*, Soushi Iwasaki, MD, PhD^*, Shingo Furuse, MD^*, and Akiyoshi Namiki, MD, PhD^*

From the *Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan; Department of Anesthesia, Oji General Hospital, Tomakomai, Japan.

Address correspondence and reprint requests to Masanori Yamauchi, Department of Anesthesiology, Sapporo Medical University School of Medicine, S1 W16 Chuo-ku, Sapporo, Hokkaido 060-8543, Japan. Address e-mail to yamauchi{at}sapmed.ac.jp.

Abstract

BACKGROUND: The effects of fentanyl with ketamine for postoperative pain are unknown. We investigated the adjuvant effects of ketamine for fentanyl patient-controlled analgesia.

METHODS: Cervical and lumbar spine surgery patients were divided into three groups: ketamine 1 mg/kg followed by 42 and 83 µg · kg^–1 · h^–1 in ketamine-1 and ketamine-2 group, respectively, and a control group. Postoperative patient-controlled analgesia fentanyl was administered with a background infusion.

RESULTS: Pain scores and analgesia requirement in the ketamine-2 group were significantly lower than those of the control group after cervical surgery. Ketamine partially improved the analgesic effects of fentanyl after lumbar surgery.

CONCLUSION: Small-dose ketamine improved the analgesic effects of fentanyl after cervical surgery.

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