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Anesth Analg 2008; 107:1041-1044
© 2008 International Anesthesia Research Society
doi: 10.1213/ane.0b013e31817f1e4a
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ANALGESIA

Continuous Low-Dose Ketamine Improves the Analgesic Effects of Fentanyl Patient-Controlled Analgesia After Cervical Spine Surgery

Masanori Yamauchi, MD, PhD*, Makoto Asano, MD, PhD{dagger}, Masanori Watanabe, MD*, Soushi Iwasaki, MD, PhD*, Shingo Furuse, MD*, and Akiyoshi Namiki, MD, PhD*

From the *Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan; {dagger}Department of Anesthesia, Oji General Hospital, Tomakomai, Japan.

Address correspondence and reprint requests to Masanori Yamauchi, Department of Anesthesiology, Sapporo Medical University School of Medicine, S1 W16 Chuo-ku, Sapporo, Hokkaido 060-8543, Japan. Address e-mail to yamauchi{at}sapmed.ac.jp.

Abstract

BACKGROUND: The effects of fentanyl with ketamine for postoperative pain are unknown. We investigated the adjuvant effects of ketamine for fentanyl patient-controlled analgesia.

METHODS: Cervical and lumbar spine surgery patients were divided into three groups: ketamine 1 mg/kg followed by 42 and 83 µg · kg–1 · h–1 in ketamine-1 and ketamine-2 group, respectively, and a control group. Postoperative patient-controlled analgesia fentanyl was administered with a background infusion.

RESULTS: Pain scores and analgesia requirement in the ketamine-2 group were significantly lower than those of the control group after cervical surgery. Ketamine partially improved the analgesic effects of fentanyl after lumbar surgery.

CONCLUSION: Small-dose ketamine improved the analgesic effects of fentanyl after cervical surgery.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2008 by the International Anesthesia Research Society.