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Anesth Analg 2008; 107:832-848
© 2008 International Anesthesia Research Society
doi: 10.1213/ane.0b013e318182aedb
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ANESTHETIC PHARMACOLOGY

Is a New Paradigm Needed to Explain How Inhaled Anesthetics Produce Immobility?

Edmond I. Eger, II, MD*, Douglas E. Raines, MD{dagger}, Steven L. Shafer, MD{ddagger}, Hugh C. Hemmings, Jr, MD, PhD§, and James M. Sonner, MD*

From the *Department of Anesthesia and Perioperative Care, University of California, San Francisco, California; {dagger}Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; {ddagger}Department of Anesthesia, Columbia University, New York City, New York; and §Departments of Anesthesiology and Pharmacology, Weill Cornell Medical College, New York City, New York.

Address correspondence and reprint requests to Dr. Edmond I Eger II, Department of Anesthesia, S-455, University of CA, San Francisco, CA 94143-0464. Address e-mail to egere{at}anesthesia.ucsf.edu.

A paradox arises from present information concerning the mechanism(s) by which inhaled anesthetics produce immobility in the face of noxious stimulation. Several findings, such as additivity, suggest a common site at which inhaled anesthetics act to produce immobility. However, two decades of focused investigation have not identified a ligand- or voltage-gated channel that alone is sufficient to mediate immobility. Indeed, most putative targets provide minimal or no mediation. For example, opioid, 5-HT3, {gamma}-aminobutyric acid type A and glutamate receptors, and potassium and calcium channels appear to be irrelevant or play only minor roles. Furthermore, no combination of actions on ligand- or voltage-gated channels seems sufficient. A few plausible targets (e.g., sodium channels) merit further study, but there remains the possibility that immobilization results from a nonspecific mechanism.




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H. C. Hemmings Jr.
Sodium channels and the synaptic mechanisms of inhaled anaesthetics
Br. J. Anaesth., July 1, 2009; 103(1): 61 - 69.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2008 by the International Anesthesia Research Society.