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Anesth Analg 2008; 107:1377-1379
© 2008 International Anesthesia Research Society
doi: 10.1213/ane.0b013e31817f90f1
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ANALGESIA

Profound Pain Reduction After Induction of Memantine Treatment in Two Patients with Severe Phantom Limb Pain

Robert J. Hackworth, MD, Kyle A. Tokarz, DO, Ian M. Fowler, MD, Scott C. Wallace, MD, and Eric T. Stedje-Larsen, MD

From the Department of Anesthesiology, Naval Medical Center San Diego, San Diego, California.

Address correspondence and reprint requests to Kyle A. Tokarz, DO, Naval Medical Center San Diego, Department of Anesthesiology, 34800 Bob Wilson Drive, San Diego, CA 92134. Address e-mail to kyle.tokarz{at}med.navy.mil.

Abstract

We present the cases of two patients who suffered severe lower extremity injuries and subsequently developed phantom limb pain (PLP) that was refractory to high dose opioids and adjunctive pain medications. Both patients were receiving large doses of oral methadone, IV hydromorphone via a patient-controlled analgesia delivery system, and adjunctive medications including tricyclic antidepressants, nonsteroidal anti-inflammatory medications, and anti-epileptics. Despite these treatments, the patients had severe PLP. Upon induction of the oral N-methyl-d-aspartate receptor antagonist memantine, both patients had a profound reduction in their PLP without any apparent side effects from the medication.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2008 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2008 by the International Anesthesia Research Society.