JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

Anesth Analg 2008; 107:1848-1854
© 2008 International Anesthesia Research Society
doi: 10.1213/ane.0b013e3181875a4d
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Video Clips
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Burch, T. M.
Right arrow Articles by DiNardo, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Burch, T. M.
Right arrow Articles by DiNardo, J. A.
Related Collections
Right arrow Cardiovascular
Right arrow Heart
Right arrow Resuscitation
Right arrow Complications
Right arrow Pediatrics

PEDIATRIC ANESTHESIOLOGY

Congenital Supravalvular Aortic Stenosis and Sudden Death Associated with Anesthesia: What’s the Mystery?

Thomas M. Burch, MD*, Francis X. McGowan, Jr, MD*, Barry D. Kussman, MBBCh*, Andrew J. Powell, MD{dagger}, and James A. DiNardo, MD*

From the *Division of Cardiac Anaesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, and {dagger}Department of Pediatrics, Children’s Hospital Boston and Harvard Medical School, Boston, Massachusetts.

Address correspondence and reprint requests to James A. DiNardo, MD, Department of Anesthesia, Children’s Hospital Boston, 300 Longwood Ave., Boston, MA 02115. Address e-mail to james.dinardo{at}childrens.harvard.edu.

Abstract

Patients with congenital supravalvular aortic stenosis and associated peripheral pulmonary artery stenoses, the majority of whom have Williams-Beuren syndrome, are inherently at risk for development of myocardial ischemia. This is particularly true in the setting of procedural sedation and anesthesia. The biventricular hypertrophy that accompanies these lesions increases myocardial oxygen consumption and compromises oxygen delivery. In addition, these patients often have direct, multifactorial compromise of coronary blood flow. In this article, we review both the pathophysiology of congenital supravalvular aortic stenosis and the literature regarding sudden death in association with sedation and anesthesia. Recommendations as to preoperative assessment and management of these patients are made based on the best available evidence.




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
M. M. Stechert and M. J. London
Aortic Sinotubular Ridge Calcification: A Common Transesophageal Echocardiography Finding with Uncertain Implications
Anesth. Analg., July 1, 2009; 109(1): 32 - 34.
[Full Text] [PDF]

Home page
 Anesth. Analg.Home page
D. C. Joffe, M. Richards, M. Eisses, B. Emerson, and J. Geiduschek
Elastin Arteriopathy and William Syndrome: Do You Feel Lucky?
Anesth. Analg., July 1, 2009; 109(1): 286 - 287.
[Full Text] [PDF]

Home page
 Anesth. Analg.Home page
J. A. DiNardo, F. X. McGowan, B. D. Kussman, A. J. Powell, and T. M. Burch
Elastin Arteriopathy and William Syndrome: Do You Feel Lucky?
Anesth. Analg., July 1, 2009; 109(1): 287 - 287.
[Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2008 by the International Anesthesia Research Society.