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TECHNOLOGY, COMPUTING, AND SIMULATION

Noninvasive Cardiac Output Measurement in Heart Failure Subjects on Circulatory Support

Rob Phillips, MPhil^*, Peter Lichtenthal, MD, Julie Sloniger, MS, Darryl Burstow, MD^*, Malcolm West, MD^*, and Jack Copeland, MD

From the *Department of Medicine, The University of Queensland, Brisbane, Australia; Department of Anesthesiology, and Department of Surgery, The University of Arizona College of Medicine, Tucson, Arizona.

Address correspondence and reprint requests to Rob Phillips, MPhil, P.O. Box J241, Coffs Harbour, 2450, New South Wales, Australia. Address e-mail to rap.echo{at}bigpond.com.

BACKGROUND: Pulmonary artery catheter (PAC) thermodilution is commonly used in the perioperative cardiac surgical intensive care unit for measurement and management of central hemodynamics despite questions about effectiveness, difficulty of use, and safety. USCOM is a noninvasive continuous wave Doppler device for direct measurement of cardiac output (CO) and is an alternative to PAC. USCOM validation has predominantly been in the cardiac surgical intensive care unit against PAC, despite the recognized limitations in reliability of the method. We compared USCOM CO measurements with the CardioWest, an orthotopic total artificial heart (TAH), in heart failure (HF) subjects during controlled interventions.

METHOD: CO, stroke volume (SV), and heart rate (HR) were measured in a blinded fashion using the CardioWest and the USCOM device in TAH HF patients. Five-hundred eight paired measures from 18 examinations of seven subjects were acquired as flow was varied by the CardioWest controller. Bland-Altman analysis was used to compare agreement.

RESULTS: Mean values and standard deviations (±sd) for CO, SV, and HR by CardioWest and USCOM were 7.33 ± 0.46 and 7.34 ± 0.51 L/min, 56.2 ± 3.8 and 56.6 ± 3.8 mL, and 131 ± 3 and 130 ± 4 bpm, respectively. CO ranged from 5.2 to 9.3 L/min. The mean differences between methods for CO, SV, and HR were –0.01 ± 0.23 L/min, –0.34 ± 1.97 mL, and 0.9 ± 2.3 bpm, respectively, with mean percentage differences of –0.3%, –0.6%, and 0.7%. The percentage limits of agreement for CO, SV, and HR were 6.4%, 7.1%, and 3.6%.

DISCUSSION: USCOM is a feasible and accurate method for noninvasive measurement and monitoring of CO in TAH HF patients and may have a wider application in diagnosis and management of cardiovascular disease.

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				K. Knobloch eComment: Non-invasive ultrasonic cardiac output monitoring in the surgical operating room Interactive CardioVascular and Thoracic Surgery, June 1, 2009; 8(6): 646 - 646. [Full Text] [PDF]