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AMBULATORY ANESTHESIOLOGY

The Effect of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Randomized, Placebo-Controlled Trial

Ismail Gögenur, MD^*, Bülent Kücükakin, MD^*, Thue Bisgaard, MD, DSc, Viggo Kristiansen, MD, Niels-Christian Hjortsø, MD, Debra J. Skene, PhD, and Jacob Rosenberg, MD, DSc^*

From the *Department of Surgical Gastroenterology D, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark; Department of Surgical Gastroenterology D, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark; and Center for Chronobiology, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, UK.

Address correspondence and reprint requests to Ismail Gögenur, Department of Surgical Gastroenterology D, University of Copenhagen, Gentofte Hospital, Niels Andersens Vej 65, DK-2900 Hellerup, Denmark. Address e-mail to ig{at}dadlnet.dk.

Abstract

BACKGROUND: In this study, we investigated whether melatonin administration could improve postoperative subjective sleep quality and reduce discomfort.

METHODS: One hundred twenty-one patients scheduled for elective ambulatory laparoscopic cholecystectomy were randomized to oral 5 mg melatonin (n = 60) or placebo (n = 61) for 3 nights after surgery. Subjective sleep quality, sleep duration, sleep timing, and subjective discomfort (fatigue, general well-being, and pain) were measured.

RESULTS: Sleep latency was significantly reduced in the melatonin group (mean [sd] 14 min [18]) compared with placebo (28 min [41]) on the first postoperative night (P = 0.015). The rest of the measured outcome variables did not differ between groups.

CONCLUSIONS: Melatonin did not improve subjective sleep quality or discomfort compared with placebo after laparoscopic cholecystectomy.

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