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Anesth Analg 2009; 108:1589-1591
© 2009 International Anesthesia Research Society
doi: 10.1213/ane.0b013e31819f1985
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CRITICAL CARE AND TRAUMA

Postoperative Intensive Care Unit Drug Fever Caused by Dexmedetomidine

Tadashi Okabe, MD, Shinhiro Takeda, MD, PhD, Shinji Akada, MD, PhD, Takashi Hongo, MD, PhD, and Atsuhiro Sakamoto, MD, PhD

From the Department of Anesthesiology and Intensive Care Medicine, Nippon Medical School, Tokyo, Japan.

Address correspondence and reprint requests to Shinhiro Takeda, MD, Department of Anesthesiology and Intensive Care Medicine, Nippon Medical School, Sendagi 1-1-5, Bunkyo-ku, Tokyo 113-8603, Japan. Address e-mail to shinhiro{at}nms.ac.jp.

Dexmedetomidine hydrochloride is a potent, highly selective {alpha}-2 adrenergic receptor agonist, broadly used as a sedative drug in intensive care units. We describe the case of a 59-yr-old patient who experienced drug fever caused by dexmedetomidine hydrochloride. The patient was transferred to the intensive care unit with an abdominal aortic aneurysm rupture. After initiation of sedation with dexmedetomidine hydrochloride, he developed pyrexia of more than 39°C. This symptom improved rapidly 7 h after stopping dexmedetomidine hydrochloride. Other possible causes (such as infection) were sequentially eliminated.







Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2009 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2009 by the International Anesthesia Research Society.