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ANALGESIA

Lidocaine Patch for Postoperative Analgesia After Radical Retropubic Prostatectomy

Ashraf S. Habib, MBBCh, MSc, FRCA^*, Thomas J. Polascik, MD, Alon Z. Weizer, MD, William D. White, MPH^*, Judd W. Moul, MD, Magdi A. ElGasim, MD^*, and Tong J. Gan, MB, FRCA^*

From the *Department of Anesthesiology, and Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical System, Durham, North Carolina.

Address correspondence and reprint requests to Ashraf S. Habib, MBBCh, MSc, FRCA, Duke University Medical System, Box 3094, Durham, NC 27710. Address e-mail to habib001{at}mc.duke.edu.

Abstract

In a prospective, double-blind, placebo-controlled study, patients undergoing radical retropubic prostatectomy under general anesthesia were randomly assigned to receive a lidocaine patch or placebo applied on each side of the wound at the end of surgery. Data were collected for 24 h after surgery. Seventy patients completed the study (36 lidocaine group, 34 placebo group). Demographics and postoperative morphine consumption were not different between the groups. However, the lidocaine patch group reported significantly less pain on coughing (19%–33% reduction) over all time periods (treatment vs placebo P < 0.0001, time x treatment P = 0.3056) and at rest (17%–32% reduction) for up to 6 h (treatment vs placebo P = 0.0003, time x treatment P = 0.0130).