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Anesth Analg 2009; 109:1049-1053
© 2009 International Anesthesia Research Society
doi: 10.1213/ane.0b013e3181adca28
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PEDIATRIC ANESTHESIOLOGY

Malignant Hyperthermia, Coexisting Disorders, and Enzymopathies: Risks and Management Options

Joan Benca, MD, and Kirk Hogan, MD, JD

From the Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Address correspondence and reprint requests to Joan Benca, MD, Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, B6/319 Clinical Science Center, 600 Highland Ave., Madison, WI 53792-3272. Address e-mail to jfbenca{at}wisc.edu or joan.benca{at}gmail.com.

Abstract

Clinical episodes and abnormal laboratory tests compatible with a diagnosis of malignant hyperthermia have been observed in patients with a diversity of syndromes, enzymopathies, and coexisting disorders thereby raising the likelihood of causal associations and heightened perioperative risk in others carrying a shared diagnosis. In the present review, we survey available published series, case reports, and the results of contracture testing in patients identified by others to be potentially predisposed to malignant hyperthermia. For most conditions, evidence for a causal relationship with malignant hyperthermia susceptibility is weak. The review concludes with suggestions for clinical management when evidence for or against an association is uncertain.




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P. J. Davis and B. W. Brandom
The Association of Malignant Hyperthermia and Unusual Disease: When You're Hot You're Hot, or Maybe Not
Anesth. Analg., October 1, 2009; 109(4): 1001 - 1003.
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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2009 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2009 by the International Anesthesia Research Society.