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ANALGESIA

A Comparison of Intravenous Oxycodone and Intravenous Morphine in Patient-Controlled Postoperative Analgesia After Laparoscopic Hysterectomy

Harald Lenz, MD^*, Leiv Sandvik, MSc, PhD^*, Erik Qvigstad, MD, PhD^*, Carl Eivind Bjerkelund, MD, and Johan Raeder, MD, PhD^*

From the *University of Oslo, Faculty Division Ullevaal University Hospital; and Department of Anesthesia, Center for Clinical Research, and Department of Gynecology and Obstetrics, Oslo University Hospital, Ullevaal, Oslo, Norway.

Address correspondence and reprint requests to Harald Lenz, MD, Department of Anesthesia, Oslo University Hospital, Ullevaal, N-0407 Oslo, Norway. Address e-mail to harald.lenz{at}medisin.uio.no.

Abstract

INTRODUCTION: In this study, we investigated the dose requirements, pain relief, and side effects of oxycodone versus morphine after surgery with visceral pain.

METHODS: Ninety-one women received IV oxycodone or morphine before the end of laparoscopic hysterectomy and then continued with patient-controlled analgesia for 24 h postoperatively.

RESULTS: The accumulated oxycodone consumption was less (13.3 ± 10.4 mg vs 22.0 ± 13.1 mg, P = 0.001) than morphine. With oxycodone, the visual analog scale scores were significantly lower in the first hour postoperatively and sedation was less during the 24-h postoperative period, P = 0.006.

CONCLUSIONS: Oxycodone was more potent than morphine for visceral pain relief but not for sedation.