This Article Full Text Full Text (PDF) All Versions of this Article: ane.0b013e3181b4874dv1 109/4/1284    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Google Scholar Articles by Chang, S.-H. Articles by Kim, D.-K. PubMed PubMed Citation Articles by Chang, S.-H. Articles by Kim, D.-K. Related Collections Pain Medicine Pain Pharmacology

---

ANALGESIA

An Evaluation of Perioperative Pregabalin for Prevention and Attenuation of Postoperative Shoulder Pain After Laparoscopic Cholecystectomy

Seong-Hwan Chang, PhD, MD^*, Hae-Won Lee, MD^*, Hae-Kyoung Kim, PhD, MD, Seong-Hyop Kim, PhD, MD, and Duk-Kyung Kim, PhD, MD

From the Departments of *Surgery, and Anesthesiology and Pain Medicine, Konkuk University School of Medicine, Seoul, South Korea.

Address correspondence and reprint requests to Duk-Kyung Kim, PhD, MD, Department of Anesthesiology and Pain Medicine, Konkuk University School of Medicine, 1 Hwayang-Dong, Gwanggin-Gu, Seoul 143-701, South Korea. Address e-mail to dikei{at}kuh.ac.kr.

Abstract

Postlaparoscopic shoulder pain (PLSP) frequently follows laparoscopic surgery. In this placebo-controlled study, we evaluated the efficacy of two perioperative doses of pregabalin 300 mg 12 h apart for preventing and attenuating PLSP after laparoscopic cholecystectomy. The frequency and severity of PLSP, need for postoperative rescue analgesia, and side effect profiles were assessed for 48 h postoperatively. In both groups, the overall incidence of PLSP did not differ significantly, and the pain score for PLSP, time to first rescue analgesia, and cumulative ketorolac consumption were similar at each timepoint. However, the 2-h postoperative incidence of oversedation was higher with pregabalin.