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The Adult Respiratory Distress Syndrome and Pancuronium Bromide

*Assistant Professor of Medicine. Department of Medicine, Louisiana State University Medical Center, Shreveport, Louisiana 71130.

Abstract

The institution and maintenance of artificial ventilation for a patient with the adult respiratory distress syndrome (ARDS) is frequently difficult because the hypoxic patient is often confused, agitated, or combative. Pancuronium bromide, a recently introduced neuromuscular blocking agent, w-as used to facilitate artificial ventilation in 6 patients with ARDS. As compared with morphine sulfate and diazepam, pancuronium bromide has fewer cardiovascular and central-nervous-system effects. It also has fewer cardiovascular effects than does curare, and its prolonged administration does not lead to a desensitization neuromuscular block as is seen with succinylcholine. However, continuous high-quality nursing care is necessary if this drug is used.

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				M. F. ROIZEN and T. W. FEELEY Drugs Five Years Later: Pancuronium Bromide Ann Intern Med, January 1, 1978; 88(1): 64 - 68. [Abstract] [PDF]