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Hemodynamic Effects of Isoflurane and Halothane in Patients with Coronary Artery Disease

JAMES E. MALLOW, MD^*, ROGER D. WHITE, MD, ROY F. CUCCHIARA, MD, and SAIT TARHAN, MD

*Resident, Department of Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901. Assistant Professor, Department of Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901.

Abstract

In 12 patients undergoing saphenous vein coronary artery bypass operations cardiovascular hemodynamics were studied in the awake state (control) and during anesthesia with isoflurane (inspired concentration, 1.24%, 7 patients) or with halothane (inspired concentration, 0.77%, 5 patients). Isoflurane anesthesia was accompanied by decreases of 19% in the cardiac in- dex (), 19% in mean arterial pressure

and 16% in heart rate (HR). Only the change in

was statistically significant. Halothane anesthesia was accompanied by decreases in (28%)

(22%), and HR (10%). The changes in and

were significant. HR did not change significantly following the induction of anesthesia with either agent. The decrease in

was similar with both agents, and, in this regard, neither agent was clearly superior for patients with occlusive coronary artery disease.