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Failure to Induce Hepatic Pathology in Animals Sensitizedto a Halothane Metabolite and Subsequently Challenged with Halothane

J. G. REVES, MD^*, and LINTON E. McCRACKEN, JR, MD

*Staff Anesthesiologist. Department of Anesthesiology, National Naval Medical Center, and Naval Medical Research Institute, Bethesda, Maryland. Research Fellow. Department of Anesthesiology, National Naval Medical Center, and Naval Medical Research Institute, Bethesda, Maryland.

Abstract

The results of this animal study confirm the induction of delayed hypersensitivity to a halothane metabolite, but the sensitization does not cause hepatic damage on subsequent halothane exposures. Before the hypothesis that hepatic necrosis following halothane has an immunologic basis can be accepted or rejected, more critical studies with different approaches must be made.