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Anesth Analg 1976; 55:263-268
© 1976 International Anesthesia Research Society
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A Comparative Study of Enflurane and Halothane Using Systolic Time Intervals

JOEL A. KAPLAN, MD*, EDWARD D. MILLER, MAJ, MC{dagger}, and DANIEL R. BAILEY, MAJ, MC{ddagger}

*Assistant Professor of Anesthesia, Emory University School of Medicine; Director, Division of Cardiothoracic Anesthesia, Emory University Hospital, Atlanta, Georgia 30322. {dagger}Assistant Chief, Anesthesia and Operative Service, Brooke Army Medical Center, San Antonio, Texas. {ddagger}Resident in Anesthesia, Brooke Army Medical Center, San Antonio, Texas.

Abstract

The effects of enflurane and halothane anesthesia on systolic time intervals were studied in 12 healthy patients. Cardiovascular measurements were made at equipotent levels of anesthesia: enflurane 1.23% end-tidal and halothane 0.65% end-tidal. These agents were studied first with 50% N2O and then without N2O. Systolic, diastolic, and mean arterial blood pressure were decreased more by enflurane than by halothane (p<0.05). However, halothane caused significantly more myocardial depression than enflurane, as indicated by a larger preejection period (PEP) and preejection period/left ventricular ejection time (PEP/ LVET) and a smaller 1/PEP2 and ejection fraction. When N2O was discontinued, both agents increased PEP and PEP/LVET and decreased 1/PEP2 and the ejection fraction.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1976 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1976 by the International Anesthesia Research Society.