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Anesth Analg 1976; 55:286-289
© 1976 International Anesthesia Research Society
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Etomidate

An Ultrashort-Acting Nonbarbiturate Agent for Anesthesia Induction

JOHN M. GOODING, DO*, and GUENTER CORSSEN, MD{dagger}

*Assistant Professor. Department of Anesthesiology, University of Alabama School of Medicine, Birmingham, Alabama 35294. {dagger}Professor and Chairman. Department of Anesthesiology, University of Alabama School of Medicine, Birmingham, Alabama 35294.

Abstract

Clinical evaluation of etomidate, an ultrashort-acting nonbarbiturate hypnotic agent, shows it to be useful for anesthetic induction in adults. It produces sleep in 1 arm-brain circulation time, metabolites apparently peaking at 7 minutes post injection. Cardioyascular and respiratory systems appear minimally affected and there is no indication of organ toxicity or other biochemical or hematologic drug-induced disturbances. Moderate pain on injection at some sites and transient myoclonia were the principal disadrantages observed.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1976 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1976 by the International Anesthesia Research Society.