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Hepatic Clearance of Lidocaine During N₂O Anesthesia in Dogs

ROBERT G. BURNEY, MD^*, and COSMO A. DiFAZIO, PhD, MD

*Assistant Professor of Anesthesiology. University of Virginia Medical Center, Charlottesville. Virginia 22903. Professor of Anesthesiology. University of Virginia Medical Center, Charlottesville. Virginia 22903.

Abstract

Lidocaine catabolism under N₂O anesthesia was evaluated in 5 dogs given a lidocaine infusion of 2 mg/lig/min for 20 minutes. Comparison of results with those of a prior similar study with halothane anesthesia showed catabolism of lidocaine to be significantly faster in the animals given N₂O. The extraction ratio for lidocaine, which did not vary with its arterial concentration, was significantly lower with halothane than with N₂O Decreased hepatic catabolism of drugs such as lidocaine should be anticipated in patients anesthetized with potent inhalation agents such as halothane.

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