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Clinical Investigation of a New Intravenous Anesthetic—Etoxadrol Hydrochloride (CL-1848C; U-37862A)

E. L. FREDERICKSON, MD^*, DAVID E. LONGNECKER, MD, and GARY W. ALLEN, MD

*Professor, Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia 30322. Associate Professor, Department of Anesthesiology, University of Virginia School of Medicine, Charlettes-ville, Virginia. Anesthesiologist, Temple, Texas.

Abstract

Twenty-eight patients were anesthetized with etoxadrol as primary agent. The anesthesia produced was characterized by profound analgesia and amnesia, while pharyngeal and laryngeal reflexes, as well as swallowing and lid reflexes, remained active. Systolic, diastolic, and pulse pressure were slightly increased, with associated tachycardia and tachypnea. A dose of 0.75 mg/kg produced anesthesia for an average of 26 (14 to 53) minutes. Alternating nystagmus was present for several hours and associated with dreams and/or visions that were pleasing to most patients. Six patients, however, had unpleasant dreams for up to 24 hours. One patient given an excessive dose (4.65 mg/kg) was cataleptic, amnesic, and analgesic for 6 days. The occurrence of unpleasant dreams and aberrations in over 20% of the patients suggests that the drug probably has little usefulness in anesthesia. However, the extreme safety of the drug (an LD₅₀ equal to some 20 to 40 times the ED₅₀) and the prolonged analgesia justified clinical testing. There was no evidence of metabolic or systemic organ system change from any of the clinical laboratory studies.